Analysis of hydrogen peroxide production in pure water: Ultrahigh versus conventional dose-rate irradiation and mechanistic insights
Background
Ultrahigh dose-rate radiation (UHDR) produces less hydrogenperoxide (H2 O2 ) in pure water, as suggested by some experimental studies, andis used as an argument for the validity of the theory that FLASH spares the normal tissue due to less reactive oxygen species (ROS) production. In contrast,most Monte Carlo simulation studies suggest the opposite.
Purpose
We aim to unveil the effect of UHDR...